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Avances en la inmunopatogenia de la hepatitis autoinmune
Resumen
Introducción: en la hepatitis autoinmune los mecanismos inmunopatogénicos no están totalmente esclarecidos, múltiples son las investigaciones en este campo, con vistas a enriquecer los conocimientos y ampliar las opciones terapéuticas.
Objetivo: sintetizar los conocimientos más recientes acerca de la inmunopatogenia de esta enfermedad.
Material y Método: se efectúa una búsqueda exhaustiva de la bibliografÃa disponible en SciELO, ScienceDirect, Google Académico y PubMed, incluyendo artÃculos de revisión, estudios experimentales, clÃnicos, de cohorte y metaanálisis.
Desarrollo: se explican los principales mecanismos de tolerancia central y periférica, asà como el papel de las subpoblaciones linfoides, las citocinas y el microambiente en la patogenia de la enfermedad.
Conclusiones: los avances en el conocimiento de la inmunopatogenia de la hepatitis autoinmune permiten una mejor comprensión de esta enfermedad y son el referente para el diseño de estrategias futuras de tratamiento.
Palabras clave
Referencias
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